HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
T. Kijima, T. L. Prince, M. Tigue, K. Yim, H. Schwartz, K. Beebe, S. Lee, M. Budzynski, H. Williams, J. Trepel, L. Sistonen, S. K. Calderwood, L. Neckers
This study shows HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction, revealing a noncanonical role for HSP90 in modulating HSF1 activity by removing HSF1 trimers from DNA.
bioRxiv · Mar 2, 2018Biochemistry