S. Lee

Single-cell RNA sequencing of peripheral blood cells identifies transcriptomic signatures in Parkinson's disease

This study uses single-cell RNA sequencing to identify immune cell-specific gene expression signatures and sex differences in Parkinson's disease patients compared to healthy controls.

A predictive framework for stop-loss variants with C-terminal extensions

The paper develops TAILVAR, a machine-learning classifier to predict the functional impact of stop-loss variants by integrating multi-omics features, and shows it outperforms existing tools.

Social Status as a Latent Variable in the Amygdala of Observers of Social Interactions

The paper shows that third-party observers infer social status from simulated dyadic interactions and that amygdala neurons encode the status of both interacting individuals.

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

This study identifies RNA dynamics as key regulators of cellular response to decitabine in AML cells using a multiomics and CRISPR approach.

Vortex light field microscopy: 3D spectral single-molecule imaging with a twist

This paper introduces vortex light field microscopy, achieving 3D spectral single-molecule imaging with 25 nm spatial and 3 nm spectral precision.

Establishing a Male-Positive Genetic Sexing Strain in the Asian Malaria Vector Anopheles stephensi

This paper applies the SEPARATOR system to Anopheles stephensi to enable male-specific genetic sexing for biocontrol, confirming evolutionary conservation of sex-specific splicing.

The neonatal Fc receptor and DPP4 are human astrovirus receptors

This study identifies FcRn and DPP4 as human astrovirus receptors and shows that targeting these factors with existing inhibitors prevents infection in human enteroid cultures.

Acidotolerant soil nitrite oxidiser 'Candidatus Nitrobacter laanbroekii' NHB1 alleviates constraints on growth of acidophilic soil ammonia oxidisers

This study characterizes the growth of Nitrobacter strain NHB1 under acidic conditions and shows its role in enhancing ammonia oxidation by acidophilic archaea in co-culture.

Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

This study shows cell crowding promotes invasion in high-grade DCIS by reducing cell volume through TRPV4 inhibition and mechanotransduction.

An intricate balancing act: Upstream and downstream frameshift co-regulatory elements

The paper investigates the RNA structures and interactions of the 5' and 3' regions of the SARS-CoV-2 frameshifting element, revealing their co-regulatory roles and implications for therapeutic interventions.

Determination of the absolute concentration of Rayleigh particles via scattering microscopy

This paper introduces iCAUNT, a method to measure the absolute concentration of nanoparticles smaller than one-tenth of the imaging light wavelength using scattering microscopy.

Quantitative Proteomics Identifies Conserved Proteins and Altered Regulation of Mucin-16 in Low Grade Serous Ovarian Cancers

The paper identifies conserved protein alterations and elevated MUC16 in low-grade serous ovarian cancers through quantitative proteomics and validation across multiple datasets.

Source-to-Tap Investigation of the Occurrence of Nontuberculous Mycobacteria in a Full-Scale Chloraminated Drinking Water System

This study investigates NTM occurrence in a chloraminated drinking water system, finding higher concentrations in summer first draw samples and highlighting the role of flushing and building plumbing in NTM persistence.

Calculating Protein-Ligand Residence Times Through State Predictive Information Bottleneck based Enhanced Sampling

This paper introduces a method to calculate protein-ligand residence times across wide timescales using deep learning and enhanced sampling.

Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice

This study shows that deleting Rbpj in hepatic progenitor cells reduces fibrosis and endothelial responses in DDC-fed mice by downregulating VCAM1 expression.

Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.

This study shows that inhibiting a non-canonical gp130 signaling pathway reduces chronic inflammation and multimorbidity in a high-fat diet model.

The Evolutionary Origins and Ancestral Features of Septins

This study investigates the evolutionary origins and ancestral features of septins by analyzing their phylogenetic distribution and structural evolution across eukaryotes.

Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK

This study identifies PLCβ4 as a key regulator of RANKL-induced osteoclastogenesis by interacting with MKK3 and p38 MAPK, showing its potential as a therapeutic target for bone diseases.

Ultraviolet B acts as a dietary restriction mimetic by targeting mitochondrial bioenergetics.

This study shows UVB exposure mimics dietary restriction by altering mitochondrial bioenergetics in C. elegans and human cells, triggering metabolic re-wiring and requiring mitochondrial fusion for recovery.

Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

This study develops a live-attenuated SARS-CoV-2 vaccine candidate, BK2102, which induces long-term immunity and is safe in animal models.

Nanogap Solid-State Single-Molecule Detection at Mars, Europa, and Microgravity Conditions

This paper develops a nanogap solid-state system for single-molecule detection under space-relevant conditions and validates its performance in microgravity and reduced gravity environments.

The sperm hook in house mice: a functional adaptation for migration and self-organised behaviour

This study investigates the role of the sperm hook in house mice, finding it aids in sperm attachment to the epithelium and facilitates synchronized movement during migration through the female reproductive tract.

Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.

Glyoxalase 1: emerging biomarker and therapeutic target in cervical cancer progression

This study identifies Glyoxalase-1 (GLO1) as significantly upregulated in cervical cancer tissues and shows its role in cancer metabolism, suggesting it as a potential biomarker and therapeutic target.

Enhancing Bone Regeneration and Osseointegration using rhPTH(1-34) and Dimeric R25CPTH(1-34) in an Osteoporotic Beagle Model

This study compares the effects of rhPTH(1-34) and dimeric R25CPTH(1-34) on bone regeneration and osseointegration in an osteoporotic beagle model, finding both improve bone parameters with the dimeric analog showing less pronounced but significant benefits.

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

Tumor Agnostic Drug Delivery with Self-Agglomerating Nanohydrogels (SANGs)

This paper develops a tumor-agnostic nanohydrogel (SANGs) platform for RNAi delivery, showing effective oncogene suppression and safety across species.

β-Cells as a Cell Factory for On-Demand Recombinant Protein Dosing: Harnessing the Neuroendocrine Cell Secretory Pathway for Controlled Release

This paper develops a β-cell-based platform for on-demand recombinant protein delivery by modifying the endogenous insulin processing pathway to produce and release therapeutic peptides like GLP-1 or glucagon.

Senolytic Treatment for Low Back Pain.

Senolytic drugs reduce low back pain by eliminating senescent cells and decreasing inflammatory factors in the intervertebral disc and spinal cord.

Three-dimensional Label-Free Measurements of Adipocyte Differentiation and Lipid Droplet Dynamics

This study uses low-coherence holotomography to track adipocyte differentiation and lipid droplet dynamics over 42 days without labeling.