T. Lazaridis

Simulations suggest a scaffolding mechanism of membrane deformation by the caveolin 8S complex

The paper uses molecular dynamics simulations to show that the 8S caveolin complex deforms membranes by adopting a concave shape and binding more strongly to spherical membranes when a residue is protonated.

Molecular origins of asymmetric proton conduction in the influenza M2 channel

This study identifies three molecular mechanisms explaining the asymmetric proton conduction in the influenza M2 channel through molecular dynamics simulations.

Distinct modes of action of IAPP oligomers on membranes

The paper models and simulates pore formation by IAPP oligomers in membranes, finding distinct structural behaviors between helical and β-structured peptides.

Lipid interactions of an actinoporin pore-forming oligomer

This study uses molecular dynamics simulations to investigate how actinoporin oligomers interact with lipid membranes, finding that phase coexistence, not specific sphingomyelin recognition, drives membrane targeting.

Mechanism of negative membrane curvature generationby I-BAR domains

This study shows that I-BAR domains generate negative membrane curvature through their higher oligomeric structure, not their intrinsic dimer curvature.