Gene flux and acid-imposed selection are the main drivers of antimicrobial resistance in broiler chicks infected with Salmonella enterica serovar Heidelberg
A. Oladeinde, Z. Abdo, M. O. Press, K. Cook, N. A. Cox, B. Zwirzitz, R. Woyda, S. M. Lakin, J. C. Thomas, T. Looft, D. E. Cosby, A. Hinton, J. Guard, E. Line, M. J. Rothrock, , C. Ritz
This study shows that antibiotic-resistant Salmonella can acquire resistance from gut commensals in antibiotic-free broiler chicks, driven by horizontal gene transfer and acidic selection pressure, suggesting antibiotic reduction alone may not limit resistance spread.
bioRxiv · Feb 25, 2021Microbiology