PEGylated recombinant Aplysia punctata ink toxin depletes arginine and lysine and inhibits growth of tumor xenografts
A. Wolkersdorfer, B. Bergmann, J. Adelmann, M. Ebbinghaus, E. Guenther, M. Gutmann, L. Hahn, R. Hurwitz, R. Kraehmer, F. Leenders, T. Luehmann, J. Schueler, L. Schmidt, M. Teifel, L. Meinel, T. Rudel
This study shows that PEGylated APIT reduces tumor growth in xenograft models by depleting arginine and lysine through amino acid oxidation.
bioRxiv · Jan 17, 2023 · PreprintCancer Biology