Calcium Sensitive Allostery Regulates the PI(4,5)P2 Binding Site of the Dysferlin C2A Domain
S. C. Otto, P. N. Reardon, T. M. Kumar, C. J. Kuykendall, C. P. Johnson
The paper identifies how calcium binding affects the dynamics of the dysferlin C2A domain's phosphoinositide binding site, revealing a mechanism for calcium-dependent membrane targeting.
bioRxiv · Feb 10, 2021 · PreprintBiophysics