Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver
H. Tsugawa, T. Ohki, S. Tsubaki, R. Tanaka, J. Matsuzaki, H. Suzuki, K. Hozumi
This study shows that Gas6, secreted by intestinal macrophages, prevents K. pneumoniae translocation to the liver in mice, but its reduction in aging allows bacterial invasion and systemic infection.
bioRxiv · Jan 19, 2023Microbiology