PROX1 transcription factor is a master regulator of myogenic and oncogenic features of rhabdomyosarcoma
N. Y. Gizaw, P. Kallio, T. Punger, M. Kinnunen, E. Gucciardo, K. Lehti, C. Haglund, T. Bohling, M. Varjosalo, M. Sampo, K. Alitalo, R. Kivela
This study identifies PROX1 as a master regulator of myogenic and oncogenic features in rhabdomyosarcoma, showing its role in stemness, tumor growth, and therapeutic potential through HDAC interactions.
bioRxiv · Apr 19, 2020 · PreprintCancer Biology