Author

C. Haglund

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Elbasani· 2 shared K. Lehti· 2 shared P. M. Ojala· 2 shared A. Grundhoff· 1 shared A. Levchenko· 1 shared A. Ristimäki· 1 shared A. Singhal· 1 shared E. Gucciardo· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

E. Elbasani

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Solid tumor growth depends on an intricate equilibrium of malignant cell states

S. R. Torborg, O. Grbovic-Huezo, A. Singhal, M. Holm, K. Wu, X. Han, Y.-J. Ho, C. Haglund, M. J. Mitchell, S. W. Lowe, L. E. Dow, K. L. Pitter, F. J. Sanchez-Rivera, A. Levchenko, T. Tammela

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

bioRxiv · Dec 30, 2023 · PreprintCancer Biology

E2F transcription factors promote tumorigenicity in pancreatic ductal adenocarcinoma

L. Bertonnier-Brouty, J. Andersson, T. Kaprio, J. Hagstrom, S. Bsharat, O. Asplund, G. Hatem, C. Haglund, H. Seppanen, R. B. Prasad, I. Artner

This study identifies E2F1 and E2F8 as key regulators promoting cell proliferation, survival, and migration in pancreatic ductal adenocarcinoma.

bioRxiv · Nov 10, 2023Cancer Biology

Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in an ovarian carcinoma model

H. Monzo, M. Hyytiäinen, E. Elbasani, K. Kalander, J. Wall, L. Moyano-Galceran, J. Tanjore Ramanathan, J. Jukonen, P. Laakkonen, A. Ristimäki, J. Carlson, K. Lehti, S. Salehi, P. Puolakkainen, C. Haglund, , P. M. Ojala

This study evaluates anti-SSEA-4 CAR-T cells in ovarian cancer models, showing efficacy against SSEA-4 positive cells but highlighting dose-dependent toxicity.

bioRxiv · Sep 2, 2022Cancer Biology

PROX1 transcription factor is a master regulator of myogenic and oncogenic features of rhabdomyosarcoma

N. Y. Gizaw, P. Kallio, T. Punger, M. Kinnunen, E. Gucciardo, K. Lehti, C. Haglund, T. Bohling, M. Varjosalo, M. Sampo, K. Alitalo, R. Kivela

This study identifies PROX1 as a master regulator of myogenic and oncogenic features in rhabdomyosarcoma, showing its role in stemness, tumor growth, and therapeutic potential through HDAC interactions.

bioRxiv · Apr 19, 2020 · PreprintCancer Biology

Oncogenic herpesvirus engages the endothelial transcription factors SOX18 and PROX1 to increase viral genome copies and virus production

S. Gramolelli, E. Elbasani, V. Nurminen, K. Tuohinto, T. Günther, R. E. Kallinen, S. P. Kaijalainen, R. Diaz, A. Grundhoff, C. Haglund, J. M. Ziegelbauer, M. Bower, M. Francois, P. M. Ojala

This study shows that SOX18 and PROX1, endothelial transcription factors, regulate KSHV lytic replication and virus production in lymphatic endothelial cells.

bioRxiv · Aug 27, 2019Microbiology