Cell Cycle Arrest of a "Zippering" Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders
T. Qu, Brandon Chacón, L. Faure, Marta Losa, Rocío Hernández-Martínez, Kelsey R. Robinson, Aragorn Jones, Steven Lisgo, J. De Anda, M. Risolino, Georgia Panagiotakos, Elizabeth J. Leslie, Igor I. Adameyko, Licia Selleri
The paper identifies a novel epithelial population, Zippering Lambda, whose cell cycle arrest is critical for facial prominence fusion and is disrupted in orofacial clefting.
bioRxiv · Jul 28, 2025 · PreprintDevelopmental Biology