Author

T. R. Lambeth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

R. Julian· 1 shared R. R. Julian· 1 shared Y. Zhang· 1 shared Z. Dai· 1 shared

Activity by Year

2020-2021 · peak 1/yr

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4 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

R. Julian

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2 papers

Recent·Most cited

BiochemistrybioRxivJun 18, 2021

Lysosomal proteolysis of amyloid beta is impeded by fibrils grown in both acidic and neutral pH environments

T. R. Lambeth, R. R. Julian

This study shows that amyloid-beta fibrils grown in neutral or acidic pH resist lysosomal proteolysis, with neutral pH fibrils being more resistant overall.

DOI 10.1021/acsomega.1c03915

experimental assay

BiochemistrybioRxivMay 7, 2020

A two-trick pony: lysosomal protease cathepsin B possesses surprising ligase activity

T. R. Lambeth, Z. Dai, Y. Zhang, R. Julian

This study identifies cathepsin B as a protease with unexpected ligase activity, showing it can both cleave and join peptides through a two-step mechanism.

DOI 10.1039/d0cb00224k

proteomicsexperimental assay