SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis
C. R. Diedrich, T. Rutledge, P. Maiello, T. M. Baranowski, A. G. White, H. J. Borish, P. Karell, F. Hopkins, J. Brown, S. M. Fortune, J. L. Flynn, Z. Ambrose, P. L. Lin
This study compares the effects of SIV infection and CD4 depletion on Mtb reactivation in a macaque model, finding that SIV promotes more severe granuloma dissemination and bacterial burden.
bioRxiv · Feb 21, 2020Immunology