Author

P. L. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:non-human primate· 9 Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Research Focus:drug response / drug discovery· 3 Assay:flow cytometry· 3 Research Focus:cell type annotation· 2 Assay:clinical cohort / trial· 2 Approach:deep learning· 2

Frequent Co-Authors

J. L. Flynn· 11 shared P. Maiello· 10 shared H. J. Borish· 7 shared S. M. Fortune· 6 shared A. G. White· 5 shared D. Mugahid· 3 shared H. P. Gideon· 3 shared J. Tomko· 3 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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11 shared papersImmunology

J. L. Flynn

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11 papers

Recent·Most cited

CD4+ T cells are homeostatic regulators during Mtb reinfection

J. Bromley, S. K. C. Ganchua, S. K. Nyquist, P. Maiello, M. Chao, H. J. Borish, M. Rodgers, J. Tomko, K. Kracinovsky, D. Mugahid, S. N. Nguyen, D. Wang, J. M. Rosenberg, E. C. Klein, H. P. Gideon, , J. L. Flynn

The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.

bioRxiv · Dec 20, 2023 · PreprintImmunology

Antibiotic treatment does not abrogate protection against Mycobacterium tuberculosis reinfection

S. K. Ganchua, P. Maiello, M. Chao, F. Hopkins, D. Mugahid, P. L. Lin, S. M. Fortune, J. L. Flynn

This study shows antibiotic treatment after primary Mtb infection reduces lung inflammation but does not eliminate protection against reinfection in macaques.

bioRxiv · Dec 19, 2023Microbiology

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

A. A. Smith, H. Su, J. Wallach, Y. Liu, P. Maiello, H. J. Borish, C. Winchell, A. W. Simonson, P. L. Lin, M. Rodgers, D. J. Filmore, J. Sakal, K. Lin, V. Vinette, D. Schnappinger, , J. L. Flynn

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

bioRxiv · Nov 22, 2023 · PreprintImmunology

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

X. Wang, H. Su, J. B. Wallach, J. C. Wagner, B. J. Braunecker, M. Gardner, K. M. Guinn, T. Klevorn, K. Lin, Y. J. Liu, Y. Liu, D. Mugahid, M. Rodgers, J. Sixsmith, S. Wakabayashi, , D. Schnappinger

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

bioRxiv · Nov 19, 2023 · PreprintMicrobiology

Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens

M. Budak, J. M. Cicchese, P. Maiello, H. J. Borish, A. G. White, H. B. Chishti, J. Tomko, L. J. Frye, D. Fillmore, K. Kracinovsky, J. Sakal, C. A. Scanga, P. L. Lin, V. Dartois, J. J. Linderman, , D. E. Kirschner

This study compares standard TB treatment with moxifloxacin-containing regimens using computational models and experimental validation to identify more effective and patient-friendly treatment options.

bioRxiv · Dec 18, 2022Pharmacology & Toxicology

Mycobacterium tuberculosis-specific CD4 T cells expressing transcription factors associate with bacterial control in granulomas

N. L. Grant, K. Kelly, P. Maiello, H. Abbott, S. L. O'Connor, P. L. Lin, C. A. Scanga, J. L. Flynn

The paper identifies Mtb-specific CD4 T cells in granulomas and shows that transcription factors T-bet and RORγT correlate with bacterial control.

bioRxiv · Nov 30, 2022 · PreprintImmunology

T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

N. L. Grant, P. Maiello, E. Klein, P. L. Lin, H. J. Borish, J. Tomko, L. J. Frye, A. G. White, D. E. Kirschner, J. T. Mattila, J. L. Flynn

This study tracks T cell transcription factor expression in granulomas of Mtb-infected macaques over time, showing increased T-bet+ T cells correlate with reduced bacterial burden.

bioRxiv · Jan 25, 2022 · PreprintImmunology

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

H. P. Gideon, T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, A. A. Tu, T. M. Gierahn, J. M. Peters, F. H. Hopkins, J.-R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Phuah, H. J. Borish, P. Maiello, , A. K. Shalek

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

bioRxiv · Oct 24, 2020 · PreprintImmunology

Evaluation of IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques

C. G. M. Winchell, B. B. Mishra, J. Y. Phuah, M. Saqib, S. J. Nelson, P. Maiello, C. M. Causgrove, C. L. Ameel, B. Stein, H. J. Borish, A. G. White, E. C. Klein, M. D. Zimmerman, V. Dartois, P. L. Lin, , J. L. Flynn

This study evaluates IL-1 blockade as an adjunct to linezolid therapy for tuberculosis in mice and macaques, finding reduced inflammation and preserved host response without impairing treatment efficacy.

Frontiers in Immunology · May 12, 2020Peer-reviewedMicrobiology

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

C. R. Diedrich, T. Rutledge, P. Maiello, T. M. Baranowski, A. G. White, H. J. Borish, P. Karell, F. Hopkins, J. Brown, S. M. Fortune, J. L. Flynn, Z. Ambrose, P. L. Lin

This study compares the effects of SIV infection and CD4 depletion on Mtb reactivation in a macaque model, finding that SIV promotes more severe granuloma dissemination and bacterial burden.

bioRxiv · Feb 21, 2020Immunology

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

J. L. Flynn, A. M. Cadena, F. H. Hopkins, P. Maiello, A. F. Carey, E. A. Wong, C. J. Martin, H. P. Gideon, R. M. DiFazio, P. Andersen, P. L. Lin, S. M. Fortune

This study shows that concurrent M. tuberculosis infection in macaques provides strong protection against secondary infection.

bioRxiv · Aug 29, 2018Microbiology