The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model
P. Yuste-Checa, V. A. Trinkaus, I. Riera-Tur, R. Imamoglu, T. Schaller, H. Wang, I. Dudanova, M. S. Hipp, A. Bracher, F. U. Hartl
This study shows that Clusterin enhances Tau aggregate seeding in a cellular model by stabilizing soluble seed species and facilitating their transfer to recipient cells.
bioRxiv · Jul 16, 2021Cell Biology