Author

T. Wellems

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:plant (other)· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

J. M. Sa· 2 shared A. M. Dondorp· 1 shared A. Simeonov· 1 shared C. A. Bewley· 1 shared C. Amaratunga· 1 shared C. Micchelli· 1 shared C. Percopo· 1 shared C. V. Hobbs· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

J. M. Sa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Progressive heterogeneity of enlarged and irregularly shaped apicoplasts in P. falciparum persister blood stages after drug treatment

C. Micchelli, C. Percopo, M. Traver, J. Brzostowski, S. N. Amin, S. T. Prigge, J. M. Sa, T. Wellems

This study examines morphological changes in apicoplasts of P. falciparum persisters after drug treatment, finding that apicoplasts become enlarged and irregularly shaped during dormancy, with variations in shape and positioning over time.

bioRxiv · Jan 3, 2024 · PreprintMicrobiology

Activity of Plasmodium vivax promoter elements in Plasmodium knowlesi, and a centromere-containing plasmid that expresses NanoLuc throughout the parasite life cycle

R. R. Moraes Barros, K. Thawnashom, T. J. Gibson, J. S. Armistead, R. L. Caleon, M. Kaneko, W. A. Kite, J. P. Mershon, J. K. Brockhurst, T. Engels, L. Lambert, S. Orr-Gonzalez, J. H. Adams, J. M. Sa, O. Kaneko, T. Wellems

This study tests the activity of Plasmodium vivax promoter elements and centromere-containing plasmids in Plasmodium knowlesi, showing functional promoters and stable plasmid expression across the parasite life cycle.

Malaria Journal · Jun 5, 2021Peer-reviewedMicrobiology

Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype

M. R. Ansbro, Z. Itkin, L. Chen, G. Zahoranszky-Kohalmi, C. Amaratunga, O. Miotto, T. Peryea, C. V. Hobbs, S. Suon, J. M. S, A. M. Dondorp, R. W. van der Pluijm, T. Wellems, A. Simeonov, R. T. Eastman

The paper evaluates drug-drug interactions in triple artemisinin-based combination therapies (TACTs) using an in vitro high-throughput process to identify genotype-dependent susceptibility and antagonism.

ACS Pharmacology & Translational Science · Dec 11, 2020Peer-reviewedMicrobiology

Isomerization of antimalarial drug WR99210 explains its inactivity in a commercial stock

T. P. Remcho, S. D. Guggilapu, P. Cruz, G. A. Nardone, G. Heffernan, R. O'Conner, C. A. Bewley, T. Wellems, K. D. Lane

The paper identifies an isomer of WR99210 that explains its inactivity, showing structural and functional differences between two commercial compounds.

bioRxiv · Jul 1, 2020Biochemistry