L. Chen

Construction of a breast cancer predictive nomogram based on diverse cell death methods and reveal tumor microenvironment characterization

The paper develops a breast cancer prognostic model and nomogram using LASSO Cox analysis and evaluates tumor microenvironment and drug sensitivity differences between subgroups.

Cell type populations for 3D anatomical structures of the Human Reference Atlas

The paper quantifies cell type populations across 3D anatomical structures using single-cell transcriptomics and proteomics data from the Human Reference Atlas.

Chronic Behavioral and Seizure Outcomes following Experimental Traumatic Brain Injury and Comorbid Klebsiella pneumoniae Lung Infection in Mice

This study investigates the long-term effects of Klebsiella pneumoniae infection following traumatic brain injury in mice, finding no significant impact on neurobehavioral outcomes or seizure development.

Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Conditioned immunological memory: implication for cognition of immune cells

This study demonstrates that immune cells can undergo classical conditioning, forming associations between hapten analogues and conjugates, leading to conditioned immunological memory and humoral immunosuppression.

Unremodeled plasma membrane GPI-anchored proteins trigger aberrant clathrin-mediated endocytosis

The paper shows that unremodeled GPI-anchored proteins in yeast cause lipid disorder and abnormal endocytosis, disrupting membrane protein trafficking.

Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct expression patterns and potential markers of progression

This study profiles proteins and glycoproteins in pancreatic neoplasms to identify expression patterns and potential progression markers.

Down regulation of Engase in Caenorhabditis elegans may improve its stresses adaptivity

This study shows that downregulating CeEngase in C. elegans enhances its adaptability to heat and osmotic stress.

GerAB residues predicted to interfere with water passage based on steered Molecular Dynamics are key to germinosome stability

The paper identifies three key residues in GerAB that affect water passage and germinosome stability through mutagenesis and molecular dynamics simulations.

EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages

This study develops a nanobody-enzyme fusion protein targeting PD-L1 and sialic acid, showing anti-tumor effects by modulating tumor-associated macrophages.

The Fem Cell-surface Signaling System is Regulated by ExsA in Pseudomonas aeruginosa and Affects Pathogenicity

The paper shows that ExsA regulates the Fem system in Pseudomonas aeruginosa, linking it to virulence factors and affecting pathogenicity in vivo.

Post-flowering photoperiod sensitivity of soybean in pod-setting responses

This study shows that soybean pod formation is sensitive to photoperiod, with LD conditions delaying pod formation and SD conditions affecting pistil morphology to influence pod-setting timing.

Perforin-mediated pore formation at the lytic synapse triggers the canonical pyroptotic cell death pathway

This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.

Gradual labeling with fluorogenic probes for MINFLUX nanoscopy of densely packed structures

This paper introduces GLF-MINFLUX, a method for nanoscale imaging of densely packed structures, achieving improved localization precision and faster acquisition.

Optimizing ex vivo CAR-T cell-mediated cytotoxicity assay through multimodality imaging

This study optimizes an ex vivo CAR-T cell-mediated cytotoxicity assay using multimodality imaging to improve real-time tracking and throughput.

High glucose treatment induced nuclei aggregation of microvascular endothelial cells via foxo1a-klf2a pathway

This study shows high glucose causes endothelial cell nuclei aggregation in zebrafish via foxo1a-klf2a pathway, linking it to microvascular complications.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia

This study identifies aquaporins in endothelial cells that regulate microvascular diameter in hyperglycemia, suggesting they are potential targets for diabetes-related vascular therapy.

Enhancing Agrobacterium-Mediated Soybean Transformation Efficiency with an Auxiliary Solution

This study improves soybean transformation efficiency using an auxiliary solution with Silwet L-77 and hormones, showing increased hairy root and hypocotyl transformation rates across varieties.

Improved vascularized lymph node transfer by periodic injection of hyaluronidase in a rodent model

This study shows that periodic hyaluronidase injections improve lymphatic drainage and reduce fibrosis in a rodent model of vascularized lymph node transfer for secondary lymphedema.

Jumbo phages possess independent synthesis and utilization systems of NAD+

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

Cure or Curse? Simulation Indicates that Microbes Proliferate under Disinfection Measures in the Space Station

This study simulates microbial proliferation in the space station under disinfection measures and finds that factors like low-dose ionizing radiation, dilution, and quaternary ammonium compound can synergistically promote microbial growth.

The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

3D live imaging and phenotyping of the subcellular cytotoxicity in cancer immunotherapy using event-triggered Bessel oblique plane microscopy

This study uses EBOPM to analyze subcellular events in CAR-T cells during immunotherapy, identifying key parameters correlated with cytotoxic function.