Contrasting responses of control and fibrotic lung fibroblasts to fibrotic stimuli: the role of osteoprotegerin in extracellular matrix remodeling
Yanzhe Liu, Mehmet Nizamoglu, Fenghua Zhao, Theo Borghuis, Taco Koster, Prashant Kumar Sharma, Martin C. Harmsen, Matthew James Thomas, Eric S. White, Karim Christian El Kasmi, Irene H. Heijink, Barbro N. Melgert, Janette Kay Burgess
This study compares OPG secretion and ECM remodeling in control and fibrotic lung fibroblasts under fibrotic conditions, finding opposite responses in matrix stiffness and collagen fiber properties.
bioRxiv · Feb 20, 2025 · PreprintCell Biology