Theo Borghuis

Type VI collagen is proportionally lower around airways and blood vessels in idiopathic pulmonary fibrosis

The paper shows that in IPF lungs, COL6 gene expression is higher but protein levels and synthesis around airways and vessels are lower, suggesting disrupted matrix organization and fibroblast persistence.

Mechanosensitive Piezo Channels Contribute to Airway Changes in Chronic Obstructive Pulmonary Disease

This study investigates the role of Piezo1/2 channels in airway smooth muscle cells of COPD patients, finding altered expression and function linked to ECM changes.

Differential collagen crosslinking and network organization creates distinct tissue remodeling patterns in fibrosis and COPD

The paper examines collagen crosslinking and organization in healthy and diseased human lungs, finding differences in crosslinking and collagen maturity between fibrotic and COPD tissues.

Collagen crosslinking and organizational patterns reflect common disease processes in idiopathic pulmonary fibrosis and non-resolving acute respiratory distress syndrome

The paper compares collagen organization and crosslinking in IPF and NR-ARDS, finding differences in collagen maturity despite similar collagen content.

A novel molecular interaction in bronchiolitis obliterans syndrome in lung transplantation patients: the role of SERPINA3 and osteoprotegerin

This study investigates the relationship between SERPINA3, osteoprotegerin (OPG), and mast cell mediators in bronchiolitis obliterans syndrome (BOS) and finds they are expressed by mast cells and may form a complex contributing to airway remodeling.

MATERNAL OBESITY MODULATES FOXO1 ACTIVATION AND ADIPOGENESIS IN NEONATAL MESENCHYMAL STEM CELLS

This study shows that maternal obesity alters FOXO1 activation and adipogenesis in neonatal mesenchymal stem cells, leading to increased adipogenic potential.

Compositional changes of the lung extracellular matrix in acute respiratory distress syndrome

This study examines compositional changes in the lung extracellular matrix across stages of acute respiratory distress syndrome (ARDS) and duration, revealing shifts in collagen and other matrix proteins.

Contrasting responses of control and fibrotic lung fibroblasts to fibrotic stimuli: the role of osteoprotegerin in extracellular matrix remodeling

This study compares OPG secretion and ECM remodeling in control and fibrotic lung fibroblasts under fibrotic conditions, finding opposite responses in matrix stiffness and collagen fiber properties.

Interaction of osteoprotegerin with fibulin-1 is essential for extracellular matrix deposition in fibrotic lung tissue

This study investigates the interaction between osteoprotegerin and fibulin-1 in lung fibrosis, finding they form a complex with fibulin-1 bridging OPG and LTBP1, influencing extracellular matrix deposition.

The lung extracellular matrix protein landscape in severe early-onset and moderate chronic obstructive pulmonary disease.

The paper compares ECM protein expression in severe-early onset and moderate COPD to controls, identifying ECM signatures linked to disease severity and subtypes.

Age-associated Differences in the Human Lung Extracellular Matrix

This study identifies seven age-associated ECM proteins with increased expression in human lung tissue and demonstrates age-related differences in specific lung compartments.