NECTIN4 defines a subtype-dependent tumor state coupling enfortumab vedotin targetability to antitumor immunity in bladder cancer
Kazuki Nishimura, Ryoichi Maenosono, Takuya Owari, Moritoshi Sakamoto, T Nishino, Kensuke Hirosuna, Takuya Tsujino, Takuya Izumi, Yuki Yoshikawa, Miyu Azuma, Sakura Inoue, Asuka Kawachi, Atsuya Ishida, Kei Nishimori, Junko Mukohyama, , Akihide Yoshimi
The paper identifies NECTIN4 as a subtype-dependent determinant of tumor state and antitumor immunity in bladder cancer, linking its expression to response to enfortumab vedotin and checkpoint inhibitors.
bioRxiv · Oct 9, 2026 · PreprintCancer Biology