Author
University of Alberta
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Mahalashmi Srinivasan, Akhil Patel, Tark Patel, Jack Moore, Erik Gomez‐Cardona, Allan Yarahmady, Brian D. Sykes, Olivier Julien, Sue‐Ann Mok
This study identifies a metabolite from E. coli that suppresses tau aggregation in vitro and in live bacteria, suggesting its potential for modulating tauopathies.
Biochemical Journal · Apr 15, 2026Peer-reviewedBiochemistry
Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Jingjie Zhu, Nessa R. Foxe, Winston T. Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue‐Ann Mok, , Wenjie Luo
This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.
Molecular Neurodegeneration · Dec 2, 2025Peer-reviewedNeuroscience
Sarah A. Naguib, Chloe Lopez-Lee, Eileen Ruth S. Torres, Se-In Lee, Jingjie Zhu, Daphne Zhu, Pearly Ye, Kendra Norman, Mingrui Zhao, Man Ying Wong, Yohannes A. Ambaw, Rodrigo Castaneda, Wei Wang, Tark Patel, Maitreyee Bhagwat, , Li Gan
The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.
bioRxiv · Apr 25, 2024 · PreprintNeuroscience
C Bravo, Alice Maria Giani, Jesús Madero‐Pérez, Zeping Zhao, Yuansong Wan, Avi J. Samelson, Man Ying Wong, Alessandro Evangelisti, Ethan Cordes, Li Fan, Pearly Ye, Daphne Zhu, Tatyana Pozner, María del Pilar Hernández Mercedes, Tark Patel, , Li Gan
The paper creates a human iPSC model of 4R tauopathy and identifies genetic modifiers of Tau propagation using CRISPRi screening.
Cell · Apr 5, 2024Peer-reviewedNeuroscience