An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses
Bennett H. Penn, Zoe Netter, Jeffrey R. Johnson, John Von Dollen, Gwendolyn M. Jang, Tasha Johnson, Yamini M. Ohol, Cyrus Maher, Samantha L. Bell, Kristina Geiger, Xiaotang Du, Alex Choi, Trevor Parry, Mayumi Naramura, Chen Chen, , Nevan J. Krogan
The paper identifies Mtb-human protein-protein interactions, showing LpqN antagonizes CBL, a host ubiquitin ligase that balances anti-viral and anti-bacterial responses in macrophages.
bioRxiv · Oct 17, 2017 · PreprintMicrobiology