An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer
Jodie R. Malcolm, Jack Stenning, Jacob Pope, Jakub Lukaszonek, Susanna F Rose, Taylor E. Smith, Lesley Gilbert, Sally R. James, Katherine S. Bridge, William J. Brackenbury, Andrew N. Holding
The paper identifies an ERα-dependent hypoxia response in ER+ breast cancer that influences gene expression and sensitivity to amiloride, linking hypoxia and ER signaling.
bioRxiv · Oct 3, 2025 · PreprintCancer Biology