DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts.
Krzysztof Kuś, Loïc Carrique, Tea Kecman, Marjorie L. Fournier, Sarah Sayed Hassanein, Ebru Aydin, Cornelia Kilchert, Jonathan M. Grimes, Lidia Vasiljeva
This study shows that Spt5 enhances Xrn2 activity to facilitate Pol II transcription termination and prevent non-coding transcript expression.
Nature Communications · Jan 2, 2025Peer-reviewedMolecular Biology