Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally
Josephine Cecelia McGowan, Jed Katzenstein, Natalie S. Chace, Camila Wagner-Sanchez, Temi Okotore, Tolu Ogunfowora, Tallie Z. Baram, Oluwarotimi O. Folorunso, William A. Carlezon
This study shows that early life stress in mice leads to social behavior deficits and altered stress biomarkers in adolescence, with effects persisting across generations.
bioRxiv · Nov 27, 2025 · PreprintNeuroscience