Siglec-G on B cells restrains the germinal center response by controlling T cell help during positive selection
Jhon R. Enterina, Sung-Yao Lin, Liany Luna-Dulcey, Susmita Sarkar, Edward N. Schmidt, Zeinab Jame-Chenarboo, Kennedy Chisholm, Arbab Ul Haq, Shu Luo, Chris D. St. Laurent, Theo Ataei, Fabrizio Giuliani, Olivier Julien, Matthew Scott Macauley
This study identifies Siglec-G as a checkpoint receptor on B cells that limits germinal center (GC) response by modulating T cell help during positive selection.
bioRxiv · May 11, 2026 · PreprintImmunology