Author

Thomas Attard

Wellcome Centre for Cell Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Joseph A. MarshiD· 2 shared Julie P. I. WelburniD· 2 shared Alan BrowniD· 1 shared Alan J. QuigleyiD· 1 shared Alex von KriegsheimiD· 1 shared Alison M. MeynertiD· 1 shared Amelia ShoemarkiD· 1 shared Amjad HoraniiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Joseph A. MarshORCID

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Author profile →

2 papers

Recent·Most cited

TUBB4B variants specifically impact ciliary function, causing a ciliopathic spectrum

Daniel O Dodd, Sabrina Méchaussier, Patricia Levy Yeyati, Fraser McPhie, Jacob R. Anderson, Chen Jing Khoo, Amelia Shoemark, Deepesh Kumar Gupta, Thomas Attard, Maimoona A. Zariwala, Marie Legendre, Diana Carolin Bracht, Julia Wallmeier, Miao Gui, Mahmoud R. Fassad, , Pleasantine Mill

The paper identifies TUBB4B mutations causing distinct ciliopathic diseases by affecting microtubule dynamics and cilia formation in humans and mice.

Science · Apr 25, 2024Peer-reviewedGenetic & Genomic Medicine

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

Thomas Attard, Julie P. I. Welburn, Joseph A. Marsh

The paper investigates tubulin mutations' molecular mechanisms and their phenotypic effects, finding that current computational methods poorly predict their pathogenicity due to dominant-negative and gain-of-function mechanisms.

PLoS Computational Biology · Oct 7, 2022Peer-reviewedGenetics