ENGINEERING AND PRECLINICAL EVALUATION OF DRIED FOOD-FORMULATED YEAST-SECRETED ANTIBODIES AS PERI-EXPOSURE PROPHYLAXIS AGAINST CLOSTRIDIOIDES DIFFICILE DISEASE.
Charlotte Roels, Marlies Ballegeer, Semiramis Yılmaz, Hendrik Grootaert, Leander Meuris, Elise Wyseure, Thomas Herman, Pieter Van Haverbeke, Sandrine Vanmarcke, Katrien Claes, Kenny Roose, Nico Callewaert
This study develops and tests dried food-formulated yeast-secreted VHH antibodies as prophylaxis against Clostridioides difficile disease in mice, showing high efficacy in preventing mortality and disease.
bioRxiv · Nov 14, 2025 · PreprintMolecular Biology