Regulators of Interferon-Responsive Microglia Uncovered by Genome-wide CRISPRi Screening
Amanda McQuade, Vincent Cele Castillo, Venus Hagan, Weiwei Liang, Thomas Ta, Reet Mishra, Olivia M. Teter, Layla Gomes, Bianca Gonzalez, Noam Teyssier, Kun Leng, Martin Kampmann
This study identifies 772 genes regulating the interferon-responsive microglia state using CRISPRi screening in human iPSC-derived microglia, including novel regulators like CNOT10.
npj Dementia · Sep 2, 2026Peer-reviewedNeuroscience