Author

Thorben Thalacker

European Molecular Biology Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Andreas H. GuseiD· 1 shared Frederike Kulow· 1 shared Henning TidowiD· 1 shared Lucas A. DefelipeiD· 1 shared María García-AlaiiD· 1 shared Michael ZimmermanniD· 1 shared Ralf FliegertiD· 1 shared Shivansh GoyaliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Andreas H. GuseORCID

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1 paper

Recent·Most cited

Domain-Specific Agonist Binding Affinities Explain Structural and Functional Regulation of TRPM2

Tatiana Kupriianova, Tessa Schwarzer, Thorben Thalacker, Lucas A. Defelipe, Stefanie Etzold, Frederike Kulow, Vanessa Pahl, Shivansh Goyal, Vanna Nguyen, Michael Zimmermann, Andreas H. Guse, Xiaolu A. Cambronne, Henning Tidow, Ralf Fliegert, María García-Alai

This study quantifies the binding affinities of TRPM2 domains for ADPR analogs and shows that MHR1/2 drives activation while NUDT9H maintains structural integrity.

bioRxiv · Apr 1, 2026 · PreprintBiophysics