Cryo-EM Structure of a Triazole alpha-Conotoxin GI Mimetic Bound to the Muscle-Type Nicotinic Acetylcholine Receptor
Oscar A. Shepperson, Michael J. Capper, Charlie Holdship, Oliver J. Melling, Nicola Wade, Michael A. Malone, Kirsty Arnott, Danielle C. Morgan, Thomas J. Piggot, Tiffany Morcom, Josephine Connah, Leonie M. Windeln, Christopher M. Timperley, Jeremy Graham Frey, Chris Green, , Andrew G. Jamieson
The paper designs and characterizes triazole-based peptidomimetics of the -GI conotoxin, showing they retain potency and provide structural insights into their interaction with the muscle-type nAChR.
bioRxiv · Sep 1, 2026 · PreprintBiochemistry