The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor
Sanne Westhoff, Tim van Leeuwe, Omar Qachach, Zheren Zhang, Gilles van Wezel, Daniel Rozen
This study shows that resistance to sub-MIC streptomycin in S. coelicolor evolves without fitness costs and involves distinct mutations compared to high-concentration resistance.
bioRxiv · Jul 6, 2016Evolutionary Biology