Evolutionary BiologybioRxiv
The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor
Sanne Westhoff, Tim van Leeuwe, Omar Qachach…·Daniel Rozen
This study shows that resistance to sub-MIC streptomycin in S. coelicolor evolves without fitness costs and involves distinct mutations compared to high-concentration resistance.
DOI 10.1038/ismej.2016.194