Tumour-derived factors prime microglia for immune checkpoint-mediated T-cell regulation
Luca D Schreurs, Jessica Barz, Trong-Hieu Nguyen, Jule Schmedding, Liudmila Lobastova, Patrick Hoelker, Tamina Seeger-Nukpezah, J. Lackmann, Jana Caroline Hollenbeck, Christina Ising, Ulf D. Kahlert, Timmer Marco, Roland Goldbrunner, Volker Neuschmelting, Phuong‐Hien Nguyen
This study identifies an early microglial activation program driven by soluble factors from tumors, leading to immune checkpoint regulation and immunosuppression in brain tumors.
bioRxiv · Oct 13, 2026 · PreprintCancer Biology