Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I
Houfu Leng, Jiahao Jiang, Katja Gassner, Swati Midha, Raquel Justo‐Méndez, Jianqing Zheng, Timothy Hall, Lin Luo, Suzanne D West, Tonia L. Vincent, Angus K. T. Wann, Kashyap Amratlal Patel, Joanna Poulton, Christopher A. O’Callaghan, Ana Victoria Lechuga‐Vieco, Anna Katharina Simon
This study shows mitochondrial heteroplasmy impairs osteoclast differentiation and bone resorption by disrupting respiratory complex I and autophagy, and identifies spermidine as a potential therapeutic agent.
bioRxiv · May 2, 2025 · PreprintCell Biology