FLIP is essential for oncogenic KRAS-driven lung cancer
Claudia Hamilton, Shaun Sharkey, Hajrah A. Khawaja, Matilda Downs, Christopher McLaughlin, Connor N. Brown, Declan F. Doherty, Jennifer Fox, Mihaela Pettigrew, Karl T. Butterworth, A.R. Phillips, Donna M. Small, Timothy Harrison, Catherine A. Higgins, Emma M. Kerr, Daniel B. Longley
This study identifies FLIP as a critical survival factor in KRAS-mutant lung cancers, revealing a KRAS-ERK-FLIP axis that protects against apoptosis and suggests FLIP as a therapeutic target.
bioRxiv · Aug 5, 2026 · PreprintCancer Biology