Author

Tom Howd

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Niall J. LennoniD· 2 shared Sheila Dodge· 2 shared Stacey GabrieliD· 2 shared Yossi FarjouniD· 2 shared Andrew Bernier· 1 shared April Jung· 1 shared Bharathi Gandi· 1 shared Brendan S. Blumenstiel· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersGenomics

Niall J. LennonORCID

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2 papers

Recent·Most cited

Cost-efficient whole genome-sequencing using novel mostly natural sequencing-by-synthesis chemistry and open fluidics platform

Gilad Almogy, Mark Pratt, Florian C. Oberstrass, Linda Lee, Dan Mazur, Nate Beckett, Omer Barad, Ilya Soifer, Eddie Perelman, Yoav Etzioni, Martin Sosa, April Jung, Tyson A. Clark, Eliane H. Trepagnier, Gila Lithwick‐Yanai, , Doron Lipson

Open flow cell on a circular wafer with mostly natural nucleotides and no reversible terminators: about 300 bp reads at $1/Gb, 99.6% SNP accuracy on reference human genomes.

bioRxiv · May 29, 2022 · PreprintGenomics

Characterization and remediation of sample index swaps by non-redundant dual indexing on massively parallel sequencing platforms

Maura Costello, Mark Fleharty, Justin Abreu, Yossi Farjoun, Steven Ferriera, Laurie Holmes, Brian R. Granger, Lisa Green, Tom Howd, Tamara Mason, Gina Vicente, Michael Dasilva, Wendy Brodeur, Timothy DeSmet, Sheila Dodge, , Stacey Gabriel

The paper characterizes index swapping on Illumina sequencers and proposes dual indexing to mitigate its effects, showing varying swap rates across methods and sequencers.

BMC Genomics · May 8, 2018Peer-reviewedGenomics