Tomoki Kishimoto

Gingipain-containing products from Porphyromonas gingivalis promote epithelial CCL20 signaling and γδ T-cell accumulation in COPD-like airways

This paper shows that Porphyromonas gingivalis gingipain products induce CCL20 signaling and γδ T-cell accumulation in COPD-like airways via PAR-2 activation.

Dietary lipid stress aggravates obstructive lung injury involving epithelial IGF-1-Akt dysfunction and epithelial-endothelial crosstalk

This study shows that high-fat diet worsens obstructive lung injury by impairing epithelial IGF-1-Akt signaling and promoting epithelial-endothelial interactions.

HDAC3 inhibition stabilizes the IL-37 receptor module to enhance anti-inflammatory signaling in cystic fibrosis airway epithelium

The paper identifies HDAC3 inhibition as a method to stabilize the IL-37 receptor module and enhance anti-inflammatory signaling in CF airway epithelial cells.

Early apelin receptor activation attenuates elastase-induced emphysema and preserves endothelial apelin receptor signaling in mice

This study shows early apelin receptor activation reduces emphysema in mice by limiting inflammation and airspace enlargement, but has no effect after disease onset.