Trang Nguyen

The paper constructs a genomic atlas of cardiac and adiposity imaging phenotypes using whole-genome sequencing data from UK Biobank, identifying genetic associations and polygenic scores linked to cardiometabolic diseases.

This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.

This study uses three protein language models to engineer TEV protease variants with improved stability and production, showing high efficiency with fewer designs.

This paper presents a computational pipeline for designing VHH nanobodies against LGR5 without structural templates, resulting in high-affinity, stable binders validated by cryo-EM.

This study shows that GPR34 maintains microglial homeostasis and limits disease-associated microglial responses in Alzheimer's disease models.

The paper identifies ancestry-specific T2D risk variants in South Asian populations through exome-wide association study and functional validation.

This paper computationally designs soluble CCR8 analogues that retain native antibody binding, achieving a 62% success rate with preserved structural and functional properties.

This study compares toxigenic and non-toxigenic Corynebacterium diphtheriae isolates to identify genomic differences between respiratory and cutaneous strains, highlighting potential virulence factors.