CD19 CAR Engineered T Regulatory Cells Promote Durable Immune Tolerance in Experimental Systemic Lupus Erythematosus
Travis Drow, Matteo Doglio, Annaiz Grimm, Victoria DeVault-Nelson, Maegan Hoover, Brock McKinney, Subhash Kumar Tripathi, Jennifer Mellen, Madison Milazewski, Payam Zarin, Alaina Burgess, Christopher L. Moore, Pierluigi Carulli, Alessia Ugolini, Clara Bercher, , David J. Rawlings
This study shows that CD19 CAR-engineered regulatory T cells reduce B cell numbers, inflammation, and autoantibodies in lupus models, promoting long-term immune tolerance.
bioRxiv · Oct 11, 2026 · PreprintImmunology