GLOBAL EFFECTS OF A PD RISK-SNP AT THE ALPHA-SYNUCLEIN LOCUS
Jordan D Prahl, Steven E. Pierce, Edwin J. C. Van der Schans, Gerhard A. Coetzee, Trevor Tyson
This study investigates the risk mechanism of rs356182, a PD risk SNP near SNCA, by generating CRISPR-Cas9 lesions in LUHMES cells and observing effects on neuronal differentiation and axonogenesis.
bioRxiv · Jul 6, 2021 · PreprintNeuroscience