An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells
L. Broadbent, C. G. G. Bamford, G. Lopez Campos, S. Manzoor, D. Courtney, A. Ali, O. Touzelet, C. McCaughey, K. Mills, U. Power
The paper shows that an endogenous IFNλ pathway provides resistance to SARS-CoV-2 in airway epithelial cells, with high baseline IFNλ correlating with resistance.
bioRxiv · Aug 17, 2021Immunology