A. Ali

Population growth poses a significant threat to forest ecosystems: a case study from the Hindukush-Himalayas of Pakistan

The paper examines how population growth in Pakistan's Malam Jabba area has accelerated deforestation, using remote sensing and a decay model to predict future trends.

In-Vivo and In-Vitro Toxicity Evaluation of 2,3-Dimethylquinoxaline: an Antimicrobial Found in a Traditional Herbal Medicine

This study evaluates the toxicity of 2,3-dimethylquinoxaline in vitro and in vivo, finding no significant toxicity except for thrombocytosis, leukocytosis, and histological changes at high doses.

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPAR alpha and PCK1 action in hepatocytes

This study shows intermittent fasting prevents NASH and HCC by PPAR alpha and PCK1 working together in liver cells.

Inhibiting the GPI Transamidase Subunit GPAA1 Abolishes CD24 Surface Localization and Enhances Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells

This study identifies GPAA1 as a regulator of CD24 surface expression and shows that inhibiting GPAA1 enhances macrophage-mediated phagocytosis of ovarian cancer cells.

The HOMEODOMAIN-Like protein HDL mediates chromatin organization and rewires leaf epidermal patterning

This study identifies HDL, a homeodomain-like protein that regulates chromatin organization and influences leaf epidermal cell fate by modulating gene expression and cell heterogeneity.

Wiskott-Aldrich Syndrome Protein Regulates Nucleolar Organization and Function in Innate Immune Response

This study shows that WASP regulates nucleolar structure and function, affecting rRNA transcription and inflammatory cytokine response in macrophages.

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts

The paper characterizes the proteome and phosphoproteome of prostate cancer patient-derived xenografts to identify differences between neuroendocrine-like and adenocarcinoma subtypes.

Surface crosslinking of virus-like particles increases resistance to proteases, low pH and mechanical stress for mucosal applications

This study enhances the stability of virus-like particles (VLPs) against environmental stressors by surface crosslinking, without affecting their vaccine function.

Indigenous probiotics Lactobacillus reuteri and Enterococcus faecium exhibit positive growth performance and disease prevention against extended-spectrum cephalosporin and fluoroquinolones resistant Salmonella enterica in broiler chicks.

This study shows that indigenous probiotics Lactobacillus reuteri and Enterococcus faecium improve growth and reduce Salmonella infection in broiler chicks compared to commercial probiotics.

Structural Basis for the Phase Separation of the Chromosome Passenger Complex

The paper identifies contact regions in the chromosome passenger complex (CPC) that drive phase separation using hydrogen/deuterium-exchange mass spectrometry.

Spatially structured host genetic diversity leads to the evolution of local specialization

This study shows that spatial structure and host genetic diversity interact to influence pathogen specialization in Plodia interpunctella hosts.

Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis.

This study identifies Grem1-articular cartilage progenitor cells as critical for maintaining joint health, and their loss leads to osteoarthritis, with potential therapeutic targeting of FGFR3.

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates

During stress, molecular chaperones preserve 'orphan' ribosomal proteins in liquid-like condensates, maintaining them in a usable form and enabling efficient recovery from stress.

Single-cell analysis of myeloid cells in HPV+ tonsillar cancer

This study uses single-cell RNA-sequencing to analyze myeloid cells in HPV+ tonsillar cancer, identifying distinct cell lineages and their impact on patient survival.

The influence of genetic structure on phenotypic diversity in the Australian mango (Mangifera indica) gene pool

This study examines how genetic structure in the Australian mango gene pool influences phenotypic diversity in tree size, fruit blush color, and intensity.

Continuous Fish Muscle Cell Line with Capacity for Myogenic and Adipogenic-like Phenotypes

The paper establishes and characterizes a continuous Atlantic mackerel skeletal muscle cell line with myogenic and adipogenic-like phenotypes.

Selection of HIV-1 for Resistance to Fifth Generation Protease Inhibitors Reveals Two Independent Pathways to High-Level Resistance

This study identifies two independent resistance pathways to fifth-generation protease inhibitors in HIV-1 by analyzing mutations under high drug concentrations.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

The paper investigates how fluorination of HCV protease inhibitors improves resistance to the D168A variant by enabling alternate binding conformations through co-crystal structure analysis.

Induction of Sis1 promotes fitness but not feedback in the heat shock response

The paper defines newly synthesized proteins as HSR activators and shows Sis1 induction enhances fitness during stress without providing negative feedback to the HSR.

Development of a monoclonal antibody to a vibriophage as a proxy for Vibrio cholerae detection

This study develops a monoclonal antibody to the vibriophage ICP1 to improve cholera detection in rapid diagnostic tests by detecting the phage as a proxy for Vibrio cholerae.

Evasion of Toll-like Receptor Recognition by Escherichia coli is mediated via Population Level Regulation of Flagellin Production

This study shows that uropathogenic E. coli evades TLR5 recognition by regulating flagellin production at the population level, not through antigenic variation.

A Novel Ex Vivo Peritoneal Model to Investigate Mechanisms of Peritoneal Metastasis in Gastric Adenocarcinoma

This paper develops an ex vivo human peritoneal explant model to study gastric adenocarcinoma metastasis and shows it responds to genetic manipulations affecting implantation.

Sugar Beet Extract Acts as a Natural Bio-Stimulant for Physio-Biochemical analysis of Hordeum Vulgare L. under Induced Salinity Stress

This study evaluates sugar beet extract's ability to mitigate salinity stress effects on barley growth and physiological traits.

An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

The paper shows that an endogenous IFNλ pathway provides resistance to SARS-CoV-2 in airway epithelial cells, with high baseline IFNλ correlating with resistance.

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression

This study produces and tests virus-free CRISPR-CAR T cells that effectively regress solid tumors in vivo.

Collaboration Between Host and Viral Factors Shape SARS-CoV-2 Evolution

This study investigates how viral and host factors influence SARS-CoV-2 evolution in vitro, identifying genetic changes and their impact on viral fitness in different cell types.

Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates

This study analyzes genetic diversity and allelic frequencies of msp-1, msp-2, and glurp in P. falciparum isolates from Pakistan, finding high genetic diversity and significant correlation between MOI and parasite density for msp-2.