Iron homeostasis governs erythroid phenotype in Polycythemia Vera
C. Bennett, V. E. Jackson, A. Pettikiriarachchi, T. Hayman, U. Schaeper, G. Moir-Meyer, K. Fielding, R. Ataide, D. Clucas, A. Baldi, A. L. Garnham, C. S. Li-Wai-Suen, W. S. Alexander, M. Bahlo, K. Burbury, , S.-R. Pasricha
This study links iron homeostasis to Polycythemia Vera by showing HFE mutations affect hepcidin expression, which regulates erythroid phenotype.
bioRxiv · May 3, 2022 · PreprintCancer Biology