Suppressing Bone Resorption and Promoting Mineralization with Tetracycline Derivatives
Saeka Shimochi, Katja Hrovat, Uruj Sarwer, Leire Bergara-Muguruza, Ari Alho, Maarit Laine, Akihisa Otaka, Yasuhiko Iwasaki, Ilkka Paatero, Ulvi Kahraman Gürsoy, Keijo T Mäkelä, Eriika Savontaus, Jukka I. Salonen, Miho Nakamura
This study evaluates the effects of tetracycline derivatives on bone cells, finding dose-dependent dual effects on osteoclasts and osteoblasts, suggesting potential as dual-function therapies for osteoporosis.
bioRxiv · Feb 25, 2026 · PreprintPharmacology & Toxicology