Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans
F. Nicoli, M. Cabral-Piccin, L. Papagno, E. Gallerani, V. Folcher, M. Dubois, E. Clave, H. Vallet, J. Frere, E. Gostick, S. Llewellyn-Lacey, D. Price, A. Toubert, J. Boddaert, A. Caputo, , V. Appay
This study identifies age-related alterations in basal lipid metabolism of naive CD8+ T cells in elderly humans, which impair their function and can be partially reversed with lipid-altering drugs.
bioRxiv · Sep 24, 2020Immunology