A. Caputo

Closing the gap in the clinical adoption of computational pathology: a standardized, open-source framework to integrate deep-learning algorithms into the laboratory information system

This paper presents a framework for integrating deep-learning models into the laboratory information system using open-source tools and HL7 standards to support clinical adoption in digital pathology.

Alterations in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers revealed by spatial transcriptomics

This study uses spatial transcriptomics to identify microenvironmental and signaling differences in preneoplastic breast tissues of BRCA1/2 mutation carriers compared to non-carriers.

Identification and characterization of an HtrA sheddase produced by Coxiella burnetii

The paper identifies and characterizes an HtrA sheddase produced by Coxiella burnetii and shows its role in cleaving E-cadherin, inducing M2 polarization, and enhancing bacterial replication.

Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans

This study identifies age-related alterations in basal lipid metabolism of naive CD8+ T cells in elderly humans, which impair their function and can be partially reversed with lipid-altering drugs.