Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low dose treatment of high-grade serous ovarian carcinoma
J. Benada, D. Bulanova, V. Azzoni, V. Petrosius, S. Ghazanfar, K. Wennerberg, C. S. Sorensen
This study shows that combining low-dose WEE1 and PKMYT1 inhibition synergistically kills ovarian cancer cells by increasing genomic instability and inflammation, and is well-tolerated in mice.
bioRxiv · Mar 31, 2023Cancer Biology