ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux
F. Martin-Sanchez, V. Compan, A. Tapia-Abellan, A. I. Gomez-Sanchez, M. C. Banos, F. I. Schmidt, P. Pelegrin
The paper shows that ASC oligomers change structure with low intracellular K+ to enhance caspase-1 recruitment, independent of NLRP3, and highlights K+ homeostasis as a key regulator of inflammasome activity.
bioRxiv · Jan 27, 2020Immunology