ImmunologybioRxiv
ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux
F. Martin-Sanchez, V. Compan, A. Tapia-Abellan…·P. Pelegrin
The paper shows that ASC oligomers change structure with low intracellular K+ to enhance caspase-1 recruitment, independent of NLRP3, and highlights K+ homeostasis as a key regulator of inflammasome activity.
DOI 10.1083/jcb.202003053