The Exon Junction Complex component EIF4A3 plays a splicing-linked oncogenic role in Pancreatic Ductal Adenocarcinoma
R. Blazquez-Encinas, E. Alors-Perez, M. T. Moreno-Montilla, V. Garcia-Vioque, M. E. Sanchez-Frias, A. Mafficini, J. L. Lopez-Canovas, C. Bousquet, M. D. Gahete, R. T. Lawlor, R. M. Luque, A. Scarpa, A. Arjona-Sanchez, S. Pedraza-Arevalo, A. Ibanez-Costa, J. P. Castano
This study identifies EIF4A3 as an oncogenic factor in PDAC by showing its overexpression correlates with poor prognosis and its role in regulating RNA splicing and tumor growth.
bioRxiv · Dec 7, 2023Cancer Biology